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胰岛素抵抗(insulin resistance,IR)和胰岛β细胞功能受损是糖尿病发生、发展的主要病理生理基础。及时确诊糖尿病,准确评估胰岛β细胞功能,早期干预是治疗糖尿病的关键。本研究对新诊断2型糖尿病患者,应用甘精胰岛素和二甲双胍联合治疗,并比较治疗前后血糖及胰岛β细胞功能(空腹C-肽、餐后2h C-肽、HOMA-β、HOMA-IR)、空腹血糖(fasting plasma glucose,FBG)、餐后两小时血糖(2 hour plasma glucose,2hPG)、糖化血红蛋白(hemoglobin A1C,HbA1c)及计算体重指数(body mass index,BMI)的变化。探讨基础胰岛素与二甲双胍联合用药对新诊断2型糖尿病高血糖患者的胰岛功能改善是否有显著作用。
Insulin resistance (IR) and impaired pancreatic β-cell function are the major pathophysiological bases for the development and progression of diabetes mellitus. Timely diagnosis of diabetes, accurate assessment of pancreatic β-cell function, early intervention is the key to the treatment of diabetes. In this study, patients with newly diagnosed type 2 diabetes mellitus were treated with combination of glargine and metformin. The levels of blood glucose and islet β-cell function (fasting C-peptide, postprandial 2h C-peptide, HOMA-β, HOMA-IR) , Fasting plasma glucose (FBG), 2 hour plasma glucose (2hPG), hemoglobin A1C (HbA1c) and body mass index (BMI). To investigate whether the combination of basal insulin and metformin can significantly improve the islet function of newly diagnosed type 2 diabetic patients with hyperglycemia.