论文部分内容阅读
通过微核试验和小鼠肝组织中谷胱甘肽 -S-转移酶 ( GST)活性、还原型谷胱甘肽 ( GSH )含量的测定 ,在哺乳动物整体水平 ,从遗传学和生化毒理学角度进一步研究了原花青素 ( PV2 0 0 0 )的抗诱变作用及其机理。结果发现 ,原花青素对环磷酰胺 ( CPA)诱发的小鼠骨髓多染红细胞 ( PCEs)微核细胞率有较强抑制作用 ,并能提高肝脏 GST活性 ,升高 GSH含量。说明原花青素对化学诱变剂引起的染色体断裂有一定保护作用 ,其作用机理可能与提高肝脏的解毒功能有关。
Through the micronucleus test and the determination of glutathione-S-transferase (GST) activity and reduced glutathione (GSH) content in mouse liver tissue, the overall level of mammals, from the point of view of genetics and biochemistry toxicology The antimutagenic effect of procyanidins (PV2 0 0 ) and its mechanism were further studied. The results showed that procyanidins had a strong inhibitory effect on the rate of micronucleated cells in mouse bone marrow polychromatic erythrocytes (PCEs) induced by cyclophosphamide (CPA), and they could increase the GST activity in the liver and increase the GSH content. This shows that procyanidins have a protective effect on chromosomal breakage caused by chemical mutagens, and its mechanism of action may be related to improving the detoxification function of the liver.