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哺乳动物sirtuin家族由7个成员组成,自SIRT1～SIRT7,其中SIRT1蛋白在高度保守核心结构域上与酵母Sir2蛋白有最高的序列相似性。Sir2及其同源类似物在模式生物中已经成为调控衰老和寿命的重要因子,Sir2还参与热量限制引起的抗衰老和延寿效应。目前哺乳动物sirtuin的研究主要集中在SIRT1蛋白分子上。哺乳动物sirtuin参与调控多种生物学效应,这些效应在衰老过程中发挥着重要的作用,为我们提供了一个全新的分子框架,利用这些结果可以开发针对衰老相关疾病的防治药物和方法,例如肥胖、糖尿病、心血管疾病及神经退行性疾病。
The mammalian sirtuin family consists of seven members, from SIRT1 to SIRT7, in which the SIRT1 protein has the highest sequence similarity to the yeast Sir2 protein in the highly conserved core domain. Sir2 and its cognate analogs have become important regulators of aging and longevity in model organisms, and Sir2 is also involved in the anti-aging and longevity effects caused by calorie restriction. At present mammalian sirtuin research focused on SIRT1 protein molecules. Mammalian sirtuins are involved in the regulation of a wide range of biological effects that play an important role in the aging process and provide us with a brand new molecular framework that can be used to develop agents and treatments for aging-related diseases such as obesity , Diabetes, cardiovascular disease and neurodegenerative diseases.