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为了解紫杉醇治疗鼻咽癌、喉癌及其他头颈部肿瘤的疗效及作用机理 ,本文分析了近年来的文献2 7篇。紫杉醇通过稳定微管、阻断细胞的有丝分裂和增殖 ,从而显著地抑制肿瘤细胞的生长并促进细胞调亡 ,在头颈部肿瘤同期放化疗中能起到放疗增敏作用 ,单独或联合其他抗癌药物治疗亦有较佳的疗效。紫杉醇是一种具有良好抗癌活性的药物 ,随着研究的深入 ,将会在头颈部肿瘤的治疗中发挥更大的作用
In order to understand the efficacy and mechanism of paclitaxel in the treatment of nasopharyngeal carcinoma, laryngeal carcinoma and other head and neck tumors, twenty-seven literatures in recent years are analyzed. Paclitaxel, by stabilizing microtubules, blocks mitosis and proliferation of cells, thereby significantly inhibiting the growth of tumor cells and promoting apoptosis, and plays a role in radiotherapy and sensitization in concurrent chemoradiotherapy of head and neck tumors, alone or in combination with other anti- Cancer drug treatment also has better efficacy. Paclitaxel is a good anticancer drug, with further research, will play a greater role in the treatment of head and neck cancer