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目的 :研究和观察Ⅲ型前胶原 (PCⅢ ) ,透明质酸 (HA)改变在结核性胸膜炎胸膜纤维化中的临床意义。方法 :用放射免疫法对 93例结核性胸膜炎患者同步进行血清 ,胸水PCⅢ ,HA检测。结果 :2 9例在治疗时已发生胸膜纤维化者 ,32例在治疗过程中后发的胸膜纤维化者 ,血清及胸水PCⅢ ,HA水平明显较 32例在治疗过程中未出现明显胸膜纤维化者高 ,分别比较均有显著性差异 (P <0 0 5 ) ,而前两者比较无显著统计学意义 (P >0 0 5 )。结论 :结核性胸膜炎有胸膜纤维化者和将发生胸膜纤维化者均存在活跃的PCⅢ、HA合成和分泌 ,高水平的PCⅢ ,HA提示有明显或进行性的胸膜纤维化存在。
Objective: To study and observe the clinical significance of the change of type Ⅲ procollagen (PC Ⅲ) and hyaluronic acid (HA) in pleural fibrosis of tuberculous pleurisy. Methods: Serum and pleural effusion PC Ⅲ and HA were detected simultaneously by radioimmunoassay in 93 patients with tuberculous pleurisy. Results: Twenty-nine cases of pleural fibrosis occurred during treatment, 32 cases of pleural fibrosis, pleural fibrosis, pleural effusion and pleural effusion PC Ⅲ, HA levels were significantly higher than the 32 cases in the course of treatment did not appear significant pleural fibrosis (P <0.05), while there was no significant difference between the former two groups (P> 0.05). CONCLUSION: Pleural fibrosis in patients with tuberculous pleurisy and pleural fibrosis will occur in both active PC Ⅲ, HA synthesis and secretion, high levels of PC Ⅲ, HA prompts the presence of significant or progressive pleural fibrosis.