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间充质干细胞(MSC)广泛存在于胎儿、成人骨髓、脂肪等不同组织中,是一种具有多向分化潜能的多能祖细胞,且具有广泛的免疫调节作用,在组织工程和免疫调节领域表现出极大的应用价值。MSC介导的免疫调节主要表现为免疫抑制,抑制细胞周期蛋白D2,发挥对各型免疫细胞非特异性的抗增殖及功能抑制效应。目前,对MSC免疫抑制的研究主要集中在吲哚胺-2,3-双加氧酶、地诺前列酮、一氧化氮等可溶性细胞因子以及调节性T细胞、T淋巴细胞、B淋巴细胞等靶细胞。现就MSC免疫调节机制的最新研究进展予以综述。
Mesenchymal stem cells (MSCs) are widely distributed in different tissues, such as fetus, adult bone marrow and adipose. They are pluripotent progenitor cells with multidirectional differentiation potential and have a wide range of immunomodulatory effects. In the field of tissue engineering and immunomodulation Show great application value. MSC-mediated immunoregulation is mainly manifested as immunosuppression, inhibition of cyclin D2, non-specific anti-proliferation and function inhibition of various types of immune cells. At present, the studies on immunosuppression of MSC mainly focus on soluble cytokines such as indoleamine-2,3-dioxygenase, dinoprostone and nitric oxide, as well as regulatory T cells, T lymphocytes and B lymphocytes Target cells. Now on the MSC immune regulatory mechanism of the latest research progress are reviewed.