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目的 :研究胃上皮化生、幽门螺杆菌 (HP)与十二指肠溃疡之间的关系。方法 :应用特殊染色方法对 6 0例十二指肠溃疡球部活检标本进行形态学观察及HP检测 ,并以 5 0例正常十二指肠粘膜作对照。结果 :胃上皮化生率球溃组 ( 81 7%)高于对照组 ( 2 6 %) (P <0 0 0 5 ) ;球部HP检出率球溃组 ( 5 0 %)高于对照组 ( 14 %) (P <0 0 0 5 ) ;球部HP94 6 %( 35 /37)生长在胃上皮化生区 ,5 4 %( 2 /37)生长在无化生区 (P <0 0 0 5 ) ;轻度、中度、重度胃上皮化生区HP检出率分别为 2 1 4 %、6 4 3%、70 .0 %,中～重度胃上皮化生区HP检出率高于轻度化生区 (P <0 0 5 )。结论 :胃上皮化生与HP相继作用 ,形成十二指肠溃疡。
Objective: To study the relationship between gastric metaplasia, Helicobacter pylori (HP) and duodenal ulcer. Methods: Sixty cases of duodenal ulcer were examined by histological examination and HP detection by special staining method. Fifty normal duodenal mucosa were used as controls. Results: Gastric epithelial metaplasia was significantly higher in the ball ulcer group (81.7%) than in the control group (26.0%) (P <0 05) (14%) (P <0 05). The bulb HP94 6% (35/37) grew in the gastric epithelial metaplasia area and 54% (2/37) in the non-metaplastic area The detection rate of HP in mild, moderate and severe gastric epithelial metaplasia were 21.4%, 64.3% and 70.0% respectively. The detection rate of HP in moderate-severe gastric epithelial metaplasia Higher than mild metaplastic zone (P <0 05). Conclusions: Gastric metaplasia and HP play a role in succession to form duodenal ulcer.