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目的观察奥曲肽对难治性贲门黏膜撕裂综合征(MWS)的疗效。方法将经常规治疗24h仍出血不止的47例MWS患者随机分为2组。治疗组(n=24)和对照组(n=23)。对照组:单用静脉注射奥美拉唑40mg,每12h1次。治疗组:加用奥曲肽(善宁)25μg/h微量泵泵入,连用3d。结果治疗组总有效率91.67%,明显优于对照组的73.91%(P<0.01)。结论对难治性MWS大出血患者,常规治疗效果不佳时,加用奥曲肽治疗效果显著。
Objective To observe the effect of octreotide on refractory cardia mucosal tearing syndrome (MWS). Methods Forty-seven patients with MWS who had been treated for more than 24 hours after conventional treatment were randomly divided into two groups. The treatment group (n = 24) and the control group (n = 23). Control group: single intravenous omeprazole 40mg, every 12h1 times. Treatment group: plus octreotide (Shanning) 25μg / h micro pump pumped into, with 3d. Results The total effective rate in the treatment group was 91.67%, which was significantly better than that in the control group (73.91%, P <0.01). Conclusions For patients with refractory MWS major bleeding, the curative effect of octreotide is significant when the conventional treatment is not effective.