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目的分析大量输血后纤维蛋白原和血小板的水平变化。方法 40例接受大手术需大量输血患者,均于输血前后对本组患者纤维原蛋白、血小板水平和凝血酶时间、凝血酶原时间及活化部分凝血活酶时间进行检测和观察,并对其结果进行分析。结果本组患者输血后12、48 h纤维蛋白原和血小板水平均低于输血前,输血后12、48 h凝血功能指标水平均优于输血前,比较差异均具有统计学意义(P<0.05)。结论大量输血后手术患者纤维蛋白原容易被溶解,血小板计数水平明显下降,故应对相关指标予以密切监测和相应处理,以减少危重并发症的发生。
Objective To analyze the changes of fibrinogen and platelet after massive transfusion. Methods Forty patients undergoing major surgery required large numbers of transfusions. The levels of fibrinogen, platelet, thrombin time, prothrombin time and activated partial thromboplastin time were measured before and after transfusion and the results were analyzed. analysis. Results The levels of fibrinogen and platelet were lower at 12 and 48 h after transfusions than those before transfusion. The levels of coagulation function at 12 and 48 h after transfusion were better than those before transfusion (P <0.05) . Conclusions After a large number of blood transfusions, fibrinogen in patients undergoing surgery is easily dissolved and the platelet count is obviously decreased. Therefore, related indicators should be closely monitored and treated accordingly to reduce the incidence of critical complications.