神经节苷脂是大多数哺乳动物细胞膜的组成成分,在神经系统中尤为丰富。脑缺血后给予单唾液酸神经节苷脂易于通过血脑屏障,模仿内源性单唾液酸神经节苷脂的某些功能,有效地减轻急性神经细胞损害,促进神经功能恢复。单唾液酸神经节苷脂对脑缺血的治疗通过双重效应发挥其作用:一是早期的抗急性兴奋毒性作用;二是加强内源性神经营养因子的效应。 Gangliosides are a component of most mammalian cell membranes and are particularly abundant in the nervous system. Monosialoganglioside administered after cerebral ischemia is easy to cross the blood-brain barrier and mimics some functions of endogenous monosialoganglioside, which can effectively reduce acute nerve cell damage and promote neurological function recovery. The treatment of cerebral ischemia with monosialoganglioside exerts its effects through a dual effect: one is the early anti-acute excitotoxicity; the other is the enhancement of the effects of endogenous neurotrophic factors.