类风湿关节炎(rheumatoid arthritis,RA)是一种以慢性滑膜炎症、进行性骨质破坏和关节功能丧失为特征的自身免疫性疾病,主要表现为进行性侵蚀性关节炎及晨僵,部分患者可出现发热、贫血、皮下结节及淋巴结肿大等关节外表现。在我国乃至亚洲,RA的发病率约为1.0%,致残率则高达15%。关于RA的发病机制尚正在不断研究和揭示中,而其与遗传、内分泌、环境、细胞凋亡及感染等众多因素 Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis, progressive bone destruction, and loss of joint function. It is mainly characterized by progressive aggressive arthritis and morning stiffness, Patients may have fever, anemia, subcutaneous nodules and lymph nodes and other extra-articular manifestations. In China and even in Asia, the incidence of RA is about 1.0% and the morbidity is as high as 15%. The pathogenesis of RA is still being studied and revealed, and its genetic, endocrine, environmental, apoptosis and infection and many other factors