In recent years,clinical studies have found that acetone concentration in exhaled breath can be taken as a characteristic marker of diabetes.Metal-oxide-semiconductor (MOS) materials are widely used in acetone gas sensors due to their low cost,high sensitivity,fast response/recovery time,and easy integration.This paper reviews recent progress in acetone sensors based on MOS materials for diabetes diagnosis.The methods of improving the performance of acetone sensor have been explored for comparison,especially in high humidity conditions.We summarize the current excellent methods of preparations of sensors based on MOSs and hope to provide some help for the progress of acetone sensors in the diagnosis of diabetes.