一般认为动脉壁中巨噬细胞转变为泡沫细胞,从而启动了动脉粥样硬化病变的发生[1]。在巨噬细胞内部,肝X受体(liver Xreceptor,LXR)及LXR诱导的信号是介导其脂代谢的重要分子基础,也是巨噬细胞致动脉粥样硬化的重要环节[2]。尼古丁被认为是烟草致动脉粥样硬化作用的主要因素,但其 Generally believed that the arterial wall of macrophages into foam cells, which initiated the occurrence of atherosclerotic lesions [1]. In macrophages, the signals induced by liver X receptor (LXR) and LXR are the important molecular basis of lipid metabolism and an important part of atherosclerosis induced by macrophages [2]. Nicotine is considered to be a major factor in the atherogenic effects of tobacco, but it does