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目的探讨盐酸纳美芬注射液治疗中、重度新生儿缺氧缺血性脑病的临床效果。方法选取2010年10月至2013年10月长春市儿童医院儿科收治的84例中、重度新生儿缺氧缺血性脑病患儿作为研究对象,按随机数字表法将其分为观察组和对照组,各42例。对照组患儿给予吸氧、降颅压、控制惊厥、维持血糖等支持及对症治疗,观察组患儿在对照组基础上给予盐酸纳美芬进行治疗,比较两组患儿的临床效果和不良反应发生情况。结果观察组患儿的总有效率明显高于对照组,差异有统计学意义(P<0.05);观察组患儿不良反应发生率明显低于对照组,差异有统计学意义(χ2=0.324,P<0.05)。结论盐酸纳美芬治疗中、重度新生儿缺氧缺血性脑病临床效果明显,不良反应发生率低。
Objective To investigate the clinical effect of nalmefene hydrochloride injection in treating moderate and severe neonatal hypoxic-ischemic encephalopathy. Methods Eighty-four children with moderate or severe neonatal hypoxic-ischemic encephalopathy were enrolled in this study from October 2010 to October 2013 in Changchun Children’s Hospital. Patients were divided into observation group and control group according to random number table method Group, each 42 cases. Children in the control group were given oxygen support, intracranial pressure reduction, seizure control, blood glucose maintenance and symptomatic treatment. Children in the observation group were treated with nalmefene hydrochloride on the basis of the control group. The clinical effects and the adverse effects of the two groups were compared Reaction occurred. Results The total effective rate in the observation group was significantly higher than that in the control group (P <0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (χ2 = 0.324, P <0.05). Conclusion Nalmefene hydrochloride is effective in treating moderate and severe hypoxic-ischemic encephalopathy in neonates with low incidence of adverse reactions.