论文部分内容阅读
目的:探讨血清白蛋白水平与冠心病严重程度的关系。方法:选择2008～2009年我院住院,行冠脉造影的患者237例,分别按临床类型、冠脉病变支数及冠脉病变积分评价冠心病严重程度,并分为非冠心病组(84例)、心绞痛组(92例),心肌梗死组(61例),入院第二天测定所有患者血清总蛋白、白蛋白及球蛋白,分析各指标与蛋白之间的相关性。结果:与非冠心病组比较,心绞痛组和心肌梗死组白蛋白水平明显降低[(40.22±3.56)g/L比(39.81±3.56)g/L比(38.68±3.43)g/L,P<0.05]。Spearman相关分析显示:血清白蛋白水平与临床类型(r=-0.18,P=0.005)、冠脉病变支数(r=-0.195,P=0.003)及冠脉病变积分(r=-0.188,P=0.004)呈显著负相关,而总蛋白、球蛋白及白球比值与临床类型、冠脉病变支数及冠脉病变积分均无显著相关(P>0.05)。结论:血清白蛋白水平与冠心病的严重程度呈负相关,白蛋白偏低可能是冠心病的危险因素。
Objective: To investigate the relationship between the serum albumin level and the severity of coronary heart disease. Methods: A total of 237 hospitalized patients undergoing coronary angiography in our hospital from 2008 to 2009 were enrolled in this study. The severity of coronary heart disease was evaluated according to the clinical type, the number of coronary lesions and the coronary artery disease score. The patients were divided into non-coronary heart disease group (84 (92 cases) and myocardial infarction group (61 cases). The serum total protein, albumin and globulin of all the patients were measured on the second day after admission, and the correlation between each index and protein was analyzed. Results: Compared with non-coronary heart disease group, albumin level in angina pectoris group and myocardial infarction group was significantly lower than that in non-coronary heart disease group [(40.22 ± 3.56) g / L vs (39.81 ± 3.56) g / L vs 38.68 ± 3.43 g / L, P < 0.05]. Spearman correlation analysis showed that the serum albumin level was significantly correlated with clinical type (r = -0.18, P = 0.005), coronary artery lesion count (r = -0.195, P = 0.003) = 0.004), while the ratio of total protein, globulin and white ball had no significant correlation with clinical type, coronary lesion count and coronary lesion score (P> 0.05). Conclusion: Serum albumin level is negatively correlated with the severity of coronary heart disease. Low albumin may be a risk factor for coronary heart disease.