目的:观察氟桂利嗪对杏仁核点燃鼠癎性发作及海马促凋亡基因Bax mRNA表达的影响。方法:建立杏仁核点燃模型,予不同剂量氟桂利嗪灌喂点燃鼠。原位杂交法检测鼠脑海马Bax mRNA表达,图像分析软件测量阳性细胞平均吸光度。结果:正常大鼠海马存在少量Bax mRNA表达阳性细胞,点燃鼠海马各区Bax mRNA表达阳性细胞数及平均吸光度增加,氟桂利嗪处理后平均吸光度下降与剂量有关。结论:氟桂利嗪具有抗癫癎效应和拮抗点燃鼠海马Bax mRNA表达的作用。 AIM: To observe the effect of flunarizine on the expression of Bax mRNA in amygdala after light-induced murine seizures and hippocampal apoptosis. Methods: The amygdala lit model was established, and different doses of flunarizine were fed to ignite mice. In situ hybridization was used to detect the expression of Bax mRNA in hippocampus of rats and the average absorbance of positive cells was measured by image analysis software. Results: There were a few Bax mRNA expression positive cells in hippocampus of normal rats. The number of Bax mRNA positive cells and the average absorbance increased in hippocampus of rats. The mean absorbance decreased with the dose of flunarizine. Conclusion: Flunarizine has anti-epileptic effects and antagonizes the expression of Bax mRNA in hippocampus of rats.