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Objective: To investigate the effects of Shenqi Fuzheng injection (参芪扶正注射液, SQFZI)on ventricular remodeling (VR) after acute myocardial infarction (AMI). Methods: Sixty patients with AMI were randomly divided into two groups and received conventional therapy and conventional therapy plus SQFZI separately. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-9 (TIMP-9) in plasma was measured on the 1st and 14th days after AMI. Results: MMP-9 and MMP-9/TIMP-9 were increased after AMI, after 2-week treatment, the level of MMP-9 and MMP-9/TIMP-9 decreased more significantly in SQFZI group than that in the conventional group (P＜0.05). Conclusion: Early treatment with SQFZI after AMI could reduce the level of MMPs and the production of collagen. It may be useful for the prevention of VR and heart failure after AMI.