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The tertiary structure of supercoiled DNA will be changed if it reacts with glyoxal undercertain conditions. By the reversible reaction of glyoxal with DNA, we have observed topo-logical transformations among different forms of supercoiled DNA. It is difficult to account for the electrophoretic behavior and the electronmicroscopicpattern of the reaction product by the Watson-Crick double helix model. We would like tosuggest a hypothesis concerning the tertiary structure of DNA which seems to be moreapplicable to the explanation of various facts and related phenomena.
The tertiary structure of supercoiled DNA will be changed if it reacts with glyoxal undercertain conditions. By the reversible reaction of glyoxal with DNA, we have observed topo-logical transformations among different forms of supercoiled DNA. It is difficult to account for the electrophoretic behavior and the electronmicroscopic pattern of the reaction product by the Watson-Crick double helix model. We would like tosuggest a hypothesis concerning the tertiary structure of DNA which seems to be moreapplicable to the explanation of various facts and related phenomena.