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目的 探讨白细胞介素 13(IL 13)、鳞状细胞癌抗原 (SccAg)及免疫球蛋白E(IgE)与毛细支气管炎 (简称毛支 )发病机制的关系。方法 用ELISA法检测 36例毛支患儿、2 6例哮喘患儿、4 0例肺炎患儿及 33例正常儿童血清IL 13、SccAg及IgE水平 ,并对结果进行统计学处理。 结果 (1)毛支患儿发作期血清IL 13(10 4 91± 18 0 5 )ng/L及SccAg(2 4 9± 0 38)ng/ml水平显著高于缓解期(85 15± 17 98)ng/L ,(2 30± 0 34)ng/ml及正常对照组 (77 2 7± 18 16 )ng/L ,(2 2 9± 0 34)ng/ml(P<0 0 5 ) ,而缓解期与正常对照组间无显著性差异 (P >0 0 5 )。 (2 )毛支发作期患儿血清IgE水平(370 91± 6 9 2 6 )kU/L显著高于缓解期 (189 4 6± 70 36 )kU/L(P <0 0 5 ) ,两组均显著高于正常对照组 (15 1 6 6± 70 17)kU/L(P <0 0 5 )。 (3)毛支发作期患儿血清IL 13、SccAg及IgE水平显著低于哮喘发作期 (14 7 0 0± 2 3 78)ng/L ,(3 0 1± 0 37)ng/ml,(6 5 9 5 2± 70 5 1)kU/L(P <0 0 0 1)。 (4 )毛支患儿发作期血清IL 13、SccAg及IgE水平显著高于肺炎组 (80 74± 18 0 8)ng/L ,(2 31± 0 35 )ng/ml,(15 2 87± 6 6 91)kU/L(P <0 0 5 )。 (5 )毛支患儿发作期血清IL 13水平与SccAg、IgE及SccAg与IgE水
Objective To investigate the relationship between interleukin-13 (IL-13), squamous cell carcinoma antigen (SccAg) and immunoglobulin E (IgE) and the pathogenesis of bronchiolitis. Methods Serum levels of IL-13, SccAg and IgE were detected by ELISA in 36 children with bronchiolitis, 26 children with asthma, 40 children with pneumonia and 33 normal children. The results were statistically analyzed. Results (1) Serum levels of IL-13 (10419 +/- 1850 ng / L) and SccAg (2949 +/- 038) ng / ml were significantly higher in patients with fulminant bronchiectasis than those in the remission stage (85 15 ± 17 98 (2 30 ± 0 34) ng / ml and normal controls (77 2 7 ± 18 16) ng / L, (2 29 ± 0 34) ng / ml respectively However, there was no significant difference between remission and normal control (P> 0.05). (2) The serum level of IgE in 370 children with fulminant epidermis (370 91 ± 6 9 2 6) was significantly higher than that in remission (189 46 ± 70 36) kU / L (P 0 05) Were significantly higher than the normal control group (15 1 6 6 ± 70 17) kU / L (P 0 05). (3) Serum levels of IL-13, SccAg and IgE were significantly lower in the children with fulminations than those in the asthmatic group (14 7 0 0 ± 2 3 78 ng / L, (3 0 1 ± 0 37) ng / 6 5 9 5 2 ± 70 5 1) kU / L (P <0 0 0 1). (4) Serum levels of IL-13, SccAg and IgE were significantly higher in the patients with fulminant bronchiectasis than those in the pneumonia group (80 74 ± 180 8 ng / L, (2 31 ± 0 35) ng / ml, (15 2 87 ± 6 6 91) kU / L (P <0 05). (5) The serum IL-13 levels in children with bronchiectasis were significantly correlated with SccAg, IgE, SccAg and IgE