卵巢切除引起渐进性骨质丢失,这与绝经后骨质疏松极为相似。破骨细胞通过与其它细胞相互作用引起骨吸收,吸收程度取决于酸性和溶酶体酶的释放,抗酒石酸酸性磷酸酶(TRAP)和碳酸酐酶Ⅱ(CA-Ⅱ)为破骨细胞骨吸收的关键性酶。本文作者应用鼠TRAP cDNA及CA-ⅡcDNA探针。经Northern印 Ovariectomy causes progressive loss of bone mass, which is very similar to postmenopausal osteoporosis. Osteoclasts cause bone resorption through interaction with other cells. The degree of absorption depends on the release of acidity and lysosomal enzymes, and the resistance to tartrate-acid phosphatase (TRAP) and carbonic anhydrase II (CA-II) to osteoclast bone resorption Of the key enzymes. The authors used murine TRAP cDNA and CA-II cDNA probes. Northern blotting