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目的:筛选健脾祛湿颗粒剂中挥发油的最佳包合工艺。方法:以挥发油转化率、包合物收率为指标,采用β-环糊精(β-CD)饱和水溶液法对挥发油进行了包合,通过正交试验探讨了包合的最佳工艺。结果:包合的最佳工艺为β-CD与挥发油的配比(g∶mL)为10∶1;包合时间为60min,包合温度为40℃,此条件下β-CD包合物的综合评分为77.34分。结论:此包合工艺提高了健脾祛湿颗粒剂中挥发油的利用率。
Objective: To screen the optimum inclusion technology of volatile oil in Jianpi Qushi Granules. Methods: The volatile oil was encapsulated by β-cyclodextrin (β-CD) saturated aqueous solution using volatile oil conversion rate and inclusion compound yield as the indexes. The optimum technology of inclusion was discussed by orthogonal test. Results: The optimum conditions for the inclusion process were as follows: the ratio of β-CD to volatile oil (g: mL) was 10:1; the inclusion time was 60min and the inclusion temperature was 40 ℃. The overall score is 77.34. Conclusion: This inclusion process improves the utilization rate of volatile oil in Jianpi Qushi Granules.