丙型肝炎病毒(HCV)是慢性病毒性肝炎的主要病原体之一,有15%～20%的HCV慢性感染患者发展为肝硬化或肝细胞癌(HCC)。HCV至少有6种基因型和60多种亚型,其中HCV-1 b亚型在亚洲甚为流行。该型具有对干扰素治疗不敏感,比其他亚型病程快,易发展为HCC等特点。研究发现HCV-1b亚型NS3的1/3 N端编码丝氨酸蛋白酶,其活性最小部分在1 059～1 204这一区域,该酶活性在NS4 Hepatitis C virus (HCV) is one of the major pathogens of chronic viral hepatitis, and cirrhosis or hepatocellular carcinoma (HCC) develops in 15% to 20% of patients with chronic HCV infection. HCV has at least 6 genotypes and more than 60 subtypes, of which HCV-1 b subtype is very prevalent in Asia. This type is not sensitive to interferon treatment, faster than other subtypes of course, easy to develop characteristics such as HCC. Study found that HCV-1b subtype NS3 1/3 N-terminal coding serine protease, the smallest part of the activity in the range of 1 059 ~ 1 204, the enzyme activity in NS4