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目的探讨乳腺粒细胞肉瘤(granulocytic sarcoma,GS)的临床病理学特征、诊断及鉴别诊断方法。方法对1例乳腺GS的临床表现、组织形态学及免疫组化特点、治疗及预后进行探讨。结果乳腺GS以乳腺肿块为首要表现,形态学上肿瘤浸润性生长,弥漫分布,细胞小,胞质少,核圆形、椭圆形、染色质细腻、核分裂易见。免疫组化肿瘤细胞MPO、CD15、CD43和溶菌酶(+)。结论乳腺GS常与急性髓细胞白血病(AML)同时或在其后发生;罕见的情况下,在急性髓细胞白血病开始出现之前形成。仅凭形态学易误诊为淋巴瘤等。免疫组化MPO、溶菌酶、CD15、CD43和CD99有助于诊断。
Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of granulocytic sarcoma (GS). Methods One case of breast GS clinical manifestations, histomorphology and immunohistochemistry characteristics, treatment and prognosis were discussed. Results The mammary gland was the first manifestation of mammary gland mass. Morphologically, tumor infiltrative growth, diffuse distribution, small cell, less cytoplasm, nuclear round, oval, fine chromatin, mitotic easy to see. Immunohistochemical tumor cells MPO, CD15, CD43 and lysozyme (+). Conclusions The mammary gland often occurs concurrently with or after acute myeloid leukemia (AML); in rare cases, it precedes the onset of acute myeloid leukemia. Just easily misdiagnosed as morphological lymphoma. Immunohistochemistry MPO, lysozyme, CD15, CD43 and CD99 contribute to the diagnosis.