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目的:比较复方甘油果糖与甘露醇治疗婴幼儿重症肺炎合并脑病的抗脑水肿疗效以及不良反应和对心肺功能的影响。方法:将36例重症肺炎合并脑病的婴幼儿随机分为甘油组和甘露醇组,分别在综合治疗基础上静脉给予10%甘油果糖或20%甘露醇5ml/kg,重度6～8h1次,轻、中度12h1次。结果:甘露醇和复方甘油均发挥抗脑水肿的作用,但两组之间的疗效差异无统计学意义(P>0.05);甘油组肾功能损害明显低于甘露醇组(P<0.05),重症肺炎的恢复时间明显短于甘露醇组(P<0.05)。结论:甘油为治疗婴幼儿重症肺炎合并脑病有效、安全、方便的理想药物,对心肺功能影响小;而甘露醇对心肺功能影响大,延长肺炎恢复时间,除极需迅速降低颅内压、抢救脑疝外不建议选用。
OBJECTIVE: To compare the anti-cerebral edema effect, side effects and cardiorespiratory function of compound glyceroglyose and mannitol in the treatment of infantile severe pneumonia complicated with encephalopathy. Methods: Thirty-six children with severe pneumonia complicated with encephalopathy were randomly divided into glycerol group and mannitol group. On the basis of comprehensive treatment, 10% glycerol fructose or 20% mannitol was given intravenously 5ml / kg and severe 6-8h1 times, respectively , Moderate 12h1 times. Results: Both mannitol and compound glycerol exerted anti-brain edema, but there was no significant difference in therapeutic effect between the two groups (P> 0.05). The renal damage in glycerol group was significantly lower than that in mannitol group (P <0.05) Pneumonia recovery time was significantly shorter than the mannitol group (P <0.05). Conclusion: Glycerol is an effective, safe and convenient drug for the treatment of severe pneumonia complicated with encephalopathy in infants and young children. It has little effect on cardiopulmonary function. However, mannitol has a great influence on cardiopulmonary function and prolongs recovery time of pneumonia. Herniation is not recommended outside.