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目的:研究马来酸桂哌齐特对大鼠脑缺血再灌注损伤的神经保护作用。方法:成年雄性大鼠60只,给予线栓法大鼠大脑中动脉阻断(MCAO)后,随机分为马来酸桂哌齐特处理组和生理盐水对照组,观察大鼠的体重变化和死亡情况;再灌注后2 h和7 d对动物进行神经功能评分;7 d时用TTC染色法比较两组脑梗死体积。结果:两组大鼠的体重(P>0.05)和总体死亡率(P>0.05)无显著差异,但马来酸桂哌齐特能明显降低MCAO 24 h内的死亡率(P<0.05);马来酸桂哌齐特能够显著改善MCAO损伤的神经功能评分,并可明显减少脑梗死体积百分比(P<0.05)。结论:马来酸桂哌齐特对大鼠脑急性缺血再灌注损伤具有一定的保护作用。
Objective: To study the neuroprotective effect of Cinepazide Maleate on cerebral ischemia-reperfusion injury in rats. Methods: Sixty male adult rats were randomly divided into cinepazide maleate group and saline control group. The rats were sacrificed after MCA occlusion (MCAO) The neurological deficits were observed 2 h and 7 d after reperfusion. The infarct volume was compared between the two groups by TTC staining on day 7. Results: There was no significant difference in body weight (P> 0.05) and overall mortality (P> 0.05) between the two groups, but cinepazide maleate significantly reduced the intracerebral hemorrhage within 24 h (P <0.05). Cinepazide maleate can significantly improve the neurological function scores of MCAO injury, and can significantly reduce the percentage of cerebral infarction volume (P <0.05). Conclusion: Cinepazide maleate has a protective effect on acute cerebral ischemia-reperfusion injury in rats.