许多新的材料提供了动脉粥样硬化病因的合理解释的基础。其基本因素,即必须条件是,作为对流体压力改变的反应,内膜细胞发生增殖。这些材料并证明了在损伤的产生与作用力的部位之间有明显的相关,这是一个较大的贡献。第二个主要的贡献是Zilversmit和Newman提出的见解,即在把脂质从内膜排出去的过程中内皮所起的作用。正常时脂质是以同等的速度进入及移出内膜的。而当内膜异常时,向动脉壁内的移动就占优势。在内膜中,亦有内源性的脂质产生,并受酶的因素所影响。在流体动力学因素引起的内膜异常的基础上,由于吸烟或暴露于汽油发动机排出物,致使一氧化碳进 Many new materials provide the basis for a reasonable explanation of the cause of atherosclerosis. The basic element, that is, the essential condition, is that intimal cells proliferate as a response to fluid pressure changes. These materials have also demonstrated that there is a clear correlation between the damage produced and the site of force, which is a greater contribution. The second major contribution is the opinion of Zilversmit and Newman that the role of the endothelium during the discharge of lipids from the intima. Normally, lipids move in and out of the intima at equal rates. When the endocardium is abnormal, the movement to the artery wall is dominant. In the endometrium, there are also endogenous lipid production, and by the enzyme factor affected. On the basis of hydrodynamic factors caused by the endometrial abnormalities due to smoking or exposure to gasoline engine emissions, resulting in carbon monoxide into