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应用抗人T淋巴细胞、B淋巴细胞的单克隆抗体，采用免疫组织化学方法，对32例人牙髓中的T淋巴细胞亚群及淋巴细胞进行了定量研究，分析了其数量与临床病程的相关性，结果表明：正常牙髓中存在极少量的T淋巴细胞，无B淋巴细胞；T、B淋巴细胞的数量及Th／Ts比值均随牙髓病的病程发展而增加；慢性牙髓炎急性发作期T淋巴细胞数量明显减少。提示：B淋巴细胞介导的体液免疫不参与牙髓局部早期免疫应答；牙髓局部的免痪状态、免疫调节与临床病程呈正相关；慢性牙髓炎急性发作期，局部细胞免疫受抑制。
T lymphocyte subsets and lymphocytes in 32 cases of human dental pulp were studied quantitatively by using monoclonal antibodies against human T lymphocytes and B lymphocytes by using immunohistochemistry. The quantity and clinical course of The results showed that there were very few T lymphocytes and no B lymphocytes in normal dental pulp. The numbers of T, B lymphocytes and the Th / Ts ratio increased with the development of endodontic disease. Chronic pulpitis Acute episodes of T lymphocytes was significantly reduced. It is suggested that B lymphocyte-mediated humoral immunity does not participate in the local early immune response of dental pulp. The non-paralyzed endodontic state and immune regulation are positively correlated with clinical course. In the acute episode of chronic pulpitis, local cellular immunity is inhibited.