Many studies in recent years have considered the potential relationship between periodontitis and lipid parameters. Currently, it is generally accepted that HDL (High-density lipoprotein) is one of the lipoproteins that play an important role in immunity and an important part of maintaining periodontal homeostasis. In this paper, the protective mechanism of HDL in periodontitis was discussed, and the adjuvant therapeutic effect of HDL in periodontitis with systemic disease was emphasized.