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目的研究ＩＬ－１β和ＩＬ－８ｍＲＮＡ的表达、髓过氧化物酶（ＭＰＯ）和超氧化物歧化酶（ＳＯＤ）活性在监测溃疡性结肠炎（ＵＣ）活动中的作用。方法分别观察溃疡性结肠炎（ＵＣ）活动期（ＡＵＣ组）患者２０例、ＵＣ非活动期（ＩＵＣ组）患者２３例、非ＵＣ肠道炎症（ＮＵＣ组）患者１４例及对照组患者１２例结肠镜粘膜活检标本的ＭＰＯ和ＳＯＤ活性及ＩＬ－１β和ＩＬ－８ｍＲＮＡ表达。ＡＵＣ组中的１４例，经治疗２个月病情稳定后重复上述指标的测定。结果以上４组患者结肠粘膜ＭＰＯ活性依次为（１９．３７±０．５４）、（１１．５９±１．４１）、（１２．９７±０．４９）和（９．４９±０．５１）Ｕ／ｇ组织，ＳＯＤ活性分别为（５．０３±１．０７）、（７．６６±０．７９）、（６．９８±０．６１）和（８．８２±０．５８）Ｕ／ｍｇ蛋白，前３组与对照组相比差异均有显著性；ＡＵＣ组与ＩＵＣ和ＮＵＣ组差异亦具显著性（Ｐ＜０．０１）。１４例ＡＵＣ组患者，治疗前后ＭＰＯ及ＳＯＤ活性分别为（１２．６１±０．７４）Ｕ／ｇ组织ｖｓ（１９．３１±０．４４）Ｕ／ｇ组织和（７．４４±０．５５）Ｕ／ｍｇ蛋白ｖｓ（５．１１±１．０５）Ｕ／ｍｇ蛋白，治疗后前者活性显著降低，后者则?
Objective To investigate the role of IL-1β and IL-8 mRNA expression, myeloperoxidase (MPO) and superoxide dismutase (SOD) in the monitoring of ulcerative colitis (UC). Methods Twenty patients with ulcerative colitis (UC) active stage (AUC group), 23 patients with UC inactive group (IUC group), 14 patients with non-UC intestinal inflammation (NUC group) and 12 patients with control group Colon mucosal biopsy specimens of MPO and SOD activity and IL-1β and IL-8 mRNA expression. AUC group of 14 patients, after treatment for 2 months, the condition was stable after the above indicators were measured. Results The MPO activity of colonic mucosa in the above four groups were (19.37 ± 0.54), (11.59 ± 1.41), (12.97 ± 0.49) and (9.49 ± 0.51) U / g tissue, SOD activity were (5.03 ± 1.07), (7.66 ± 0.79), (6.98 ± 0.61) and (8.82 ± 0.58) U / mg protein. There was significant difference between the first three groups and the control group; the difference between AUC group and IUC and NUC group was also significant (P <0.01). In 14 AUC patients, the activity of MPO and SOD before and after treatment were (12.61 ± 0.74) U / g vs 19.31 ± 0.44 U / g and (7.44 ± 0.55) ) U / mg protein vs (5.11 ± 1.05) U / mg protein, after treatment, the former activity was significantly reduced, while the latter?