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目的分析研究银杏叶片治疗燃煤型慢性砷中毒肝损害及其对患者PAF、血清抗氧化指标的影响,探讨临床意义。方法 32例燃煤型慢性砷中毒患者,随机分为银杏叶片组与安慰片组,各16例。安慰片组患者服用安慰片,银杏叶片组患者服用银杏叶片,对比观察两组患者临床效果及治疗前后ALT、ALB、TNF-α、PAF、PCⅢ、LN、C-IV、HA及血清抗氧化指标变化情况。结果银杏叶片组总有效率为87.5%,安慰片组为62.5%,比较差异有统计学意义(P<0.05);治疗前银杏叶片组与安慰片组ALT、ALB、TNF-α、PAF、PCⅢ、LN、C-IV、HA及血清抗氧化指标水平比较差异无统计学意义(P>0.05);经治疗,银杏叶片组各项指标水平均明显优于安慰片组,差异有统计学意义(P<0.05)。结论采用银杏叶片治疗燃煤型砷中毒患者效果显著,可有效改善其临床症状及慢性肝损伤程度,该药物具有强力的PAF拮抗作用,不仅能阻断细胞因子间连锁反应,还可发挥抗脂质过氧化的功效,从而降低氧自由基对肝细胞的损害。
Objective To analyze the effect of Ginkgo biloba leaf on hepatic damage of coal-fired chronic arsenic poisoning and its effects on PAF and serum anti-oxidant in patients with chronic arsenic poisoning, and to explore its clinical significance. Methods Thirty-two patients with chronic arsenic poisoning were randomly divided into ginkgo leaf group and placebo group, with 16 cases in each group. The patients in the placebo group took placebo tablets and the patients in the ginkgo leaf group took ginkgo leaf. The clinical effects and the levels of ALT, ALB, TNF-α, PAF, PCⅢ, LN, C-IV and HA before and after treatment were compared between the two groups Changes. Results The total effective rate of Ginkgo biloba group was 87.5% and that of comfort tablet group was 62.5% (P <0.05). The levels of ALT, ALB, TNF-α, PAF, PCⅢ , LN, C-IV, HA and serum antioxidant index levels were not significantly different (P> 0.05); after treatment, the indicators of Ginkgo biloba group were significantly better than the placebo group, the difference was statistically significant P <0.05). Conclusion Ginkgo biloba leaves treatment of patients with coal-fired arsenic poisoning effect is significant, which can effectively improve their clinical symptoms and chronic liver injury, the drug has a strong PAF antagonistic effect, not only can block the chain reaction between cytokines, but also play a role in anti-lipid Peroxidation effect, thereby reducing the oxygen free radicals damage to the liver cells.