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目的:研究与甘草配伍前后,附子化学组分在煎煮过程中的动态变化规律,以确定附子配伍甘草的最佳煎煮条件。方法:测定不同时间附子单煎液和附子-甘草合煎液中乌头总碱及3种双酯型生物碱的含量,确定最佳煎煮条件;考察最佳煎煮工艺所得汤液的大鼠心脏毒性。结果:附子-甘草配伍的最佳煎煮条件为大火煮沸后小火微沸保持30 min;在煎煮0～90 min时,附子-甘草配伍前后的乌头总碱及3种双酯型生物碱的含量呈现不同的变化趋势,30 min时达两者综合的峰值;煎煮30 min的单附煎液和附子-甘草合煎液均表现出一定的大鼠毒性,但合煎液心脏毒性较小。结论:优选的配伍煎煮工艺可为中药复方及临床应用中附子的“减毒存性”提供参考。
OBJECTIVE: To study the dynamic changes of the chemical components of Radix Aconiti Preparata during and after the compatibility with licorice to determine the best boiling conditions of Radix Aconiti concomitant with licorice. Methods: The content of aconitum alkaloids and three di-ester alkaloids in aconite decoction and aconite-licorice decoction at different time were determined to determine the optimal decocting conditions. The optimum boiling conditions Rat cardiotoxicity. Results: The optimal decoction of aconite-licorice compatibility was that after the small fire was boiled, the micro-boil was kept for 30 min; the aconitum alkaloids before and after the combination of aconite-licorice and the three diester-type organisms The content of alkali showed different trend, reaching the peak value of the combination at 30 min. The decoction of Shanfu decoction and the aconite - licorice decoction decocted for 30 min all showed some toxicity to rats, but the decoction cardiotoxicity Smaller. CONCLUSION: The optimal compatibility decoction process can provide a reference for the “attenuated deposit” of aconite in traditional Chinese medicine and clinical application.