目的探讨吲哚美辛的抗癫作用,为开发新的临床应用提供依据。方法选择经临床及脑电图确诊的难治性癫患者83例,给予吲哚美辛12.5～225mg/d治疗。结果吲哚美辛治疗难治性癫总有效率84.3%,且无严重副作用。结论吲哚美辛用于难治性癫的辅助治疗,疗效显著,尤其对成人较青少年疗效更佳。 Objective To investigate the anti-epileptic effects of indomethacin and provide evidence for the development of new clinical applications. Methods 83 patients with refractory epilepsy diagnosed by clinical and electroencephalography were enrolled. Indomethacin 12.5 ~ 225mg / d was given. Results indomethacin treatment of refractory epilepsy total efficiency of 84.3%, and no serious side effects. Conclusion Indomethacin is used in the adjuvant therapy of refractory epilepsy, with significant curative effect, especially for adults who are more effective than adolescents.