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目的探讨成人急性髓系白血病(AML)患者中 NPM1基因与 FLT3基因内部串联重复(ITD)突变发生的关系,并了解其临床特征及预后。方法86例成人(15～73岁,中位年龄48.4岁)AML 患者均来自2005年1月至2006年2月我单位门诊和住院初诊病例,其中正常核型 AML50例;
Objective To investigate the relationship between the NPM1 gene and the internal tandem duplication (ITD) mutation of FLT3 gene in adult patients with acute myeloid leukemia (AML) and its clinical characteristics and prognosis. Methods A total of 86 adult patients (aged 15-73 years with a median age of 48.4 years) with AML were recruited from January 2005 to February 2006 with 50 newly diagnosed cases of AML,