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目的研究血管紧张素转换酶(ACE)基因插入/缺失(I/D)多态性与原发性高血压(EH)合并缺血性脑卒中(IS)(EH+IS)的关系。方法检索1997年1月～2010年10月4个中国著名科技期刊全文数据库和Medline中收录的有关ACE基因I/D多态性与EH+IS的病例对照研究的文献,按纳入、排除标准选择文献,并采用RevMan 5.0软件进行Meta分析。结果共纳入12项病例对照研究,其中EH+IS患者1068例,EH患者1225例。Meta分析结果表明,EH人群携带D等位基因和DD基因型者发生IS的危险性分别明显高于I等位基因和非DD基因型者,合并OR分别为1.50(95%CI:1.33～1.70)和1.83(95%CI:1.32～2.55);而携带II基因型者发生IS危险性要低于非II基因型者,合并OR为0.63(95%CI:0.53～0.76)。结论 ACE基因I/D多态性与EH人群IS的发病有密切关系,D等位基因和DD基因型是IS的危险因素。
Objective To investigate the relationship between ACE gene insertion / deletion (I / D) polymorphism and essential hypertension (EH) with ischemic stroke (IS) (EH + IS). Methods From January 1997 to October 2010, four Chinese famous scientific and technical journals full-text database and Medline contained in the ACE gene ACE polymorphism and EH + IS case-control study of the literature, according to inclusion and exclusion criteria selection Literature, and Meta-analysis using RevMan 5.0 software. Results A total of 12 case-control studies were included, of which 1068 were EH + IS patients and 1225 were EH patients. The results of Meta analysis showed that the risk of developing IS in the EH population was significantly higher than those in the I and non-DD genotypes (OR = 1.50, 95% CI: 1.33-1.70, respectively) ) And 1.83 (95% CI: 1.32-2.55). However, those with genotype II had lower IS risk than non-genotype II with a combined OR of 0.63 (95% CI: 0.53-0.76). Conclusion ACE gene I / D polymorphism is closely related to the pathogenesis of IS in EH population. D allele and DD genotype are risk factors for IS.