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目的 研究胃癌组织中nm2 3和CD44的表达 ,以及与淋巴结转移和预后的关系。方法 应用SP免疫组化技术对 10 5例胃癌组织nm 2 3、CD44H和CD44V6的表达进行观察 ,并对其中 5 9例患者随访。结果 nm2 3、CD44H及CD44V6蛋白表达阳性率分别为 44.8%、5 4.3 %和 48.6% ;nm2 3及CD44V6在胃癌组织的表达与其分化、浸润深度、临床分期和预后有关 ,而CD44H的表达与上述临床病理指标无关。 3种抗体的阳性反应与淋巴结转移有关 (nm 2 3P <0 .0 5 ;CD44V6P <0 .0 1;CD44HP <0 .0 5 )。结论 CD44H的表达可用于监测病情 ,而nm 2 3和CD44V6有希望作为一个判断预后的指标。
Objective To study the expression of nm23 and CD44 in gastric carcinoma and its relationship with lymph node metastasis and prognosis. Methods The expressions of nm 2 3, CD44H and CD44V6 in 105 cases of gastric cancer were observed by SP immunohistochemistry and 59 cases were followed up. Results The positive rates of nm23, CD44H and CD44V6 were 44.8%, 53.3% and 48.6% respectively. The expressions of nm23 and CD44V6 in gastric cancer were related to their differentiation, depth of invasion, clinical stage and prognosis. However, Clinical and pathological indicators have nothing to do. The positive reaction of the three kinds of antibodies was related to the lymph node metastasis (nm 2 3P <0. 05; CD44V6P <0. 01; CD44HP <0. 05). Conclusion CD44H expression can be used to monitor the disease, while nm 2 3 and CD44V6 hope as a prognostic indicator.