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[目的]比较兰索拉唑单用与兰索拉唑+氟哌噻吨美利曲辛联用治疗伴有负面情绪的糜烂性胃炎的疗效。[方法]将120例伴有负面情绪的糜烂性胃炎患者纳入研究,随机分为观察组和对照组。对照组60例患者口服兰索拉唑肠溶片(湖北科益药业股份有限公司产品),15mg/次,2次/d。观察组60例患者在对照组的基础上加服氟哌噻吨美利曲片,1片/次、2次/d,2组均4周为一疗程。观察2组患者治疗前后的临床症状和黏膜糜烂情况、胃黏膜中前列腺素E2(PGE2)、丙二醛(MDA)含量、焦虑和抑郁情绪的情况。[结果]①治疗后,观察组患者的临床症状评分、黏膜糜烂评分均低于对照组,差异有统计学意义(P<0.05)。②治疗后,观察组患者的HAMD评分、HAMA评分低于治疗前,差异有统计学意义(P<0.05),对照组患者负面情绪评分与治疗前的差异无统计学意义(P>0.05);③观察组患者的PGE2含量高于对照组、MDA含量低于对照组,差异有统计学意义(P<0.05)。[结论]兰索拉唑+氟哌噻吨美利曲辛联用有助于改善临床症状和黏膜糜烂、缓解负面情绪,其整体疗效优于兰索拉唑单药治疗。
[Objective] To compare the efficacy of lansoprazole alone with lansoprazole + flupentixol and melitracen in the treatment of erosive gastritis with negative emotions. [Methods] 120 patients with erosive gastritis with negative emotion were included in the study and randomly divided into observation group and control group. Control group of 60 patients oral lansoprazole enteric-coated tablets (Hubei Branch Yi Pharmaceutical Co., Ltd. products), 15mg / times, 2 times / d. The observation group of 60 patients on the basis of the control group plus flupentixol MTV, 1/2 times / d, 2 groups were 4 weeks for a course of treatment. The clinical symptoms and mucosal erosions, the content of prostaglandin E2 (PGE2), malondialdehyde (MDA), anxiety and depression in gastric mucosa were observed before and after treatment. [Results] ① After treatment, clinical symptom score and mucosal erosion score in observation group were lower than those in control group, the difference was statistically significant (P <0.05). ② After treatment, HAMD score and HAMA score in observation group were lower than those before treatment (P <0.05). There was no significant difference between negative emotion score and control before treatment in control group (P> 0.05). ③ The PGE2 content in the observation group was higher than that in the control group, and the content of MDA was lower than that in the control group (P <0.05). [Conclusions] Lansoprazole + flupentixol combined with melitracen can improve the clinical symptoms and mucosal erosion and relieve the negative emotions. Its overall curative effect is superior to that of lansoprazole monotherapy.