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已经公认曼氏血吸虫感染鼠是研究肝纤维化过程的好模式。鼠血吸虫病肝纤维化经治疗后是否逆转的问题,不同的研究方法往往得出不同的结论,肝纤维化在治疗后是消退、可逆或相对不可逆,其中接受治疗的早晚和追踪观察的长短(受实验鼠寿命的限制)两个重要的因素。另外,研究的药物不同也可能产生不同的结果。当前,吡喹酮在临床和实验研究方面的广泛应用,也未能证明其对免疫和纤维组织的直接作用. 作者观察了吡喹酮治疗对血吸虫病鼠肝纤维化的影响。用瑞士雄性小白鼠80只(8周龄,26～32
It has been recognized that Schistosoma mansoni-infected mice are a good model for studying the process of liver fibrosis. Schistosoma japonicum liver fibrosis after treatment whether the reversal of the problem, different research methods often come to different conclusions, liver fibrosis after treatment is regressive, reversible or relatively irreversible, including the treatment of morning and evening and follow-up observation of the length of ( Limited by the life of the experimental mouse) two important factors. In addition, the study of different drugs may also produce different results. Currently, praziquantel has been widely used in clinical and experimental studies and has not been able to demonstrate its direct effect on immunity and fibrosis. The authors examined the effect of praziquantel on liver fibrosis in schistosomiasis mice. 80 Swiss male mice (8 weeks old, 26 ~ 32