目的　探讨人细小病毒B19与早期先兆流产之间的关系。方法　于 2 0 0 2年 1～ 12月采用ELISA技术检测 2 6 2例正常孕妇及 32 0例早期先兆流产妇女血清中人细小病毒B19IgM含量 ,并将其结果进行对照。 结果　观察组检出人细小病毒B19IgM阳性 6 5例 ,阳性检出率 2 0 31% ;对照组 8例阳性 ,阳性检出率 3 0 5 % ,差异有显著性 ( P <0 0 5 )。感染与未感染B19病毒早期先兆流产妇女经治疗后流产率比较差异有显著的统计学意义(P <0 0 5 )。结论　人细小病毒B19可能是引起早期先兆流产的重要原因之一 Objective To explore the relationship between human parvovirus B19 and early threatened abortion. Methods From January to December in 2002, the serum levels of human parvovirus B19IgM in 266 pregnant women and 320 women with early threatened abortion were detected by ELISA, and the results were compared with each other. Results In the observation group, 65 cases were positive for B19IgM, the positive rate was 2031%. The positive rate was 35% in the control group, with a positive rate of 30.5% (P <0.05). There were significant differences in the abortion rate between the women with early threatened abortion and the non-infected B19 virus (P <0.05). Conclusions Human parvovirus B19 may be one of the important causes of early threatened abortion