论文部分内容阅读
目的 探讨慢性乙型肝炎肝窦及窦周隙内病变及其与肝纤维化的关系。方法采用 ＨＥ、特殊染色及免疫组织化学染色法，用光镜观察肝组织病理分级诊断为Ｇ_１－Ｇ_４和活动性肝硬化（ＡＬＣ）各３０例，慢性重型肝炎（ＣＳＨ）１０例的肝活检组织中各成分的分布。设正常肝５例和肝硬化（ＬＣ）１０例作对照。结果肝窦及窦周隙病理改变有塌陷、扩张、阻塞及狭窄。平滑肌肌动蛋白分布演变尤具特征性，ＣＩＶ、ＦＮ和ＬＮ三种成分在肝窦沉积与平滑肌肌动蛋白一致。它们主要分布于变性、炎症、坏死区及纤维束（隔）内。特殊染色三种纤维在肝组织中也逐级增多，在肝窦中多见网状及胶原纤维沉积，至ＡＬＣ及ＬＣ则弹力纤维增多。结论肝窦及窦周隙是肝纤维化及肝硬化的起始部位；在慢性肝炎肝组织分级、分期诊断时应该充分重视肝窦及窦周隙的病理改变。
Objective To investigate the relationship between liver fibrosis and hepatic sinusoidal lesions in chronic hepatitis B patients. Methods HE, special staining and immunohistochemical staining were used to observe the histopathological grade of liver biopsy in 30 patients with G 1-G 4 and active cirrhosis (ALC) and 10 with chronic severe hepatitis (CSH) In the distribution of the ingredients. Five cases of normal liver and 10 cases of cirrhosis (LC) were set as controls. Results The pathological changes of sinusoids and sinusoids were collapsed, dilated, blocked and stenosed. Smooth muscle actin distribution evolution is particularly characteristic, CIV, FN and LN three components in sinusoidal deposition consistent with smooth muscle actin. They are mainly located in the degeneration, inflammation, necrosis area and fiber bundle (interval). Special staining of three fibers in the liver tissue also gradually increased in the liver sinus network and collagen fibers more common deposition, to the ALC and LC elastic fibers increased. Conclusion Hepatic sinusoid and sinus perimeter are the initial sites of hepatic fibrosis and cirrhosis. In the classification and staging of chronic hepatitis, the pathological changes of hepatic sinusoid and sinusoid should be fully taken into account.