论文部分内容阅读
本文研究了正常妇女,正常妊娠妇女及妊高征患者脂质过氧化作用和抗氧化作用的变化及其与血栓素B(?)(TXB_2)、6-酮-前列腺素 F(?)(6—keto—PGF(?))的相关关系,同时观察了抗氧化剂维生素 E(VE)治疗妊高征的临床效果.结果表明,正常妊娠的脂质过氧化物(LPO)随孕龄增加而增加,VE 水平亦随孕龄增加而增加;妊高征患者 LPO 水平与同孕龄妊娠妇女相比明显升高,VE 则显著下降.LPO 与 TXB_2呈显著正相关,与6—keto—PGF(?)呈显著负相关.结果提示,LPO 与 VE 的失衡可能与妊高征发病有关.LPO 参与妊高征的发生与发展,一方面可能通过脂质过氧化损伤,另一方面影响血栓素(TXA_2)和前列环素(PGI_2)的合成.根据 VE 抗氧化作用原理,我们采用 VE 作为妊高征的辅助治疗.结果表明,VE 治疗组效果优于单纯硫酸镁组,且其病理生理变化得到改善,故 VE 是妊高征治疗中一个值得推荐的药物.
In this paper, we studied the changes of lipid peroxidation and antioxidation in normal women, normal pregnant women and patients with pregnancy induced hypertension (PIH) and their relationship with the changes of TXB_2, 6-keto-prostaglandin F (? -keto-PGF (?)), And observed the clinical effect of anti-vitamin E (VE) in the treatment of PIH.The results showed that LPO in normal pregnancy increased with gestational age , VE levels also increased with increasing gestational age; LPO levels in patients with PIH were significantly increased compared with pregnant women at gestational age, VE was significantly decreased.LPO and TXB_2 showed a significant positive correlation with 6-keto-PGF (? ) Showed a significant negative correlation.The results suggest that the LPO and VE imbalance may be related to the pathogenesis of pregnancy induced hypertension.LPO is involved in the occurrence and development of PIH.It may be through the lipid peroxidation injury on the one hand and thromboxane TXA_2 ) And prostacyclin (PGI_2) .In accordance with the principle of VE anti-oxidation, we used VE as adjuvant therapy for PIH.The results showed that VE treatment group was better than magnesium sulfate group, and its pathophysiological changes were improved , So VE is a worthy recommended medicine in PIH treatment.