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目的探讨探索奥美拉唑西沙比利与治疗反流性食道炎的临床效果。方法选取2014年2月-2015年8月医院反流性食道炎患者81例。随机分为单用药组40例和联合用药组41例。单用药组仅予奥美拉唑治疗;联合用药组予奥美拉唑与西沙比利联合治疗。比较2组总有效率,不良反应发生率及患者胃黏膜充血消退时间、溃疡愈合时间。结果联合用药组总有效率95.12%明显高于单用药组的75.00%,差异有统计学意义(P<0.05)。联合用药组的胃黏膜充血消退时间、溃疡愈合时间明显较单用药组短,差异有统计学意义(P<0.05)。2组均未出现明显不良反应,2组比较差异有统计学意义(P<0.05)。结论奥美拉唑与西沙比利联合治疗反流性食道炎的临床效果确切,可有效促进临床症状消退,安全性高,值得推广。
Objective To explore the clinical efficacy of omeprazole and cisapride in the treatment of reflux esophagitis. Methods From February 2014 to August 2015, 81 patients with reflux esophagitis were selected. Randomly divided into single-use group of 40 cases and combination group of 41 cases. The single treatment group was only treated with omeprazole; the combined treatment group was treated with omeprazole and cisapride. The total effective rate was compared between the two groups, the incidence of adverse reactions and gastric mucosal congestion in patients with subsided time, ulcer healing time. Results The total effective rate of combination group was 95.12%, which was significantly higher than that of single group (75.00%), the difference was statistically significant (P <0.05). Gastric mucosal remission time and ulcer healing time in the combination group were significantly shorter than those in the single drug group (P <0.05). No significant adverse reactions were found in both groups, the difference between the two groups was statistically significant (P <0.05). Conclusion The combination of omeprazole and cisapride in the treatment of reflux esophagitis has the exact clinical effect, which can effectively promote the regression of clinical symptoms, which is safe and worthy of promotion.