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血管内皮细胞(vascular endothelial cell,VEC)作为血液与组织之间的屏障,参与多种生理和病理过程,其功能异常与动脉粥样硬化、高血压、糖尿病等有紧密的联系[1?4]。血管紧张素Ⅱ(angiotensin-Ⅱ,Ang-Ⅱ)可促进内皮细胞内活性氧自由基(reactiveoxygen species,ROS)的生成,改变胞内Ca2+
As a barrier between blood and tissue, vascular endothelial cell (VEC) is involved in many physiological and pathological processes. Its dysfunction is closely related to atherosclerosis, hypertension, diabetes and so on [1-4] . Angiotensin Ⅱ (Ang-Ⅱ) can promote the production of reactive oxygen species (ROS) in endothelial cells and change the intracellular Ca2 +