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目的：对氟脲脱氧核苷（ＦＵＤＲ）和氟脲嘧啶（５－ＦＵ）治疗乳腺癌的疗效进行临床评价。方法：选择３０例病例采用ＣＭＦ化疗方案进行术前化疗并分组对照，治疗组使用含ＦＵＤＲ的方案，对照组使用含５－ＦＵ的方案。结果：临床观察表明对照组的ＣＲ３例，ＰＲ２例，无效８例，总有效率４６％；治疗组的ＣＲ２例，ＰＲ１５例，总有效率１００％。结论：乳腺癌患者在术前行２～４周化疗，且采用含ＦＵＤＲ的ＣＭＦ方案，可获得更高的肿瘤缓解率，便于手术；同时ＦＵＤＲ可减低全身毒性反应，从而改善治疗的疗效指数。
Objective: To evaluate the efficacy of FUDR and 5-FU in the treatment of breast cancer. Methods: Thirty cases were treated with CMF chemotherapy before chemotherapy and divided into groups. The treatment group received the FUDR-containing regimen and the control group received the 5-FU regimen. Results: The clinical observation showed that there were CR3 cases, PR2 cases and 8 cases ineffective in the control group, with a total effective rate of 46%. CR2 cases and PR15 cases in the treatment group showed a total effective rate of 100%. Conclusions: Breast cancer patients underwent chemotherapy for 2 to 4 weeks before operation, and the FUDR-containing CMF regimen can achieve higher tumor remission rate and facilitate operation. At the same time, FUDR can reduce the systemic toxicity and improve the therapeutic efficacy index.