自 Bordet 氏(1936)提出白喉类毒素与百日咳菌苗可制成联合制剂之后,Schutze、Mathieson 和 Kendrick 等氏相继报告了百白二联在动物及人体的试验结果,一般都认为免疫效果良好。此后,Lapin 氏(1943)又将百白二联加入破伤风类毒素进行人群免疫,也获得了满意结果。自此,百白二联及百白破三联逐渐在全世界推广。经过国内外学者多年来的实践证明:应用这两种联合制剂不仅可以简化免疫程序还可以提高免疫效果。因此,目前许多国家 Since Bordet’s (1936) proposed diphtheria toxoid and pertussis vaccine can be made into a combination of preparations, Schutze, Mathieson and Kendrick et al. Have reported the results of the trial of baibudian in animals and humans one after another, generally considered good immune effect. Since then, Lapin’s (1943) in turn Baipi two joined tetanus toxoid for population immunization, also obtained satisfactory results. Since then, Bai Bai Di Lian and Baibiao broken Triple gradually promoted throughout the world. After years of domestic and foreign scholars have proved that: the use of these two combination preparations can not only simplify the immune process can also improve the immune effect. Therefore, many countries at present