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为了解妊高征病人机体凝血与纤溶功能的改变，选择重度妊高征病人２４例为妊高征组，选择同期３０例正常孕妇为对照组。应用免疫凝胶火箭电泳法检测两组血浆抗凝血酶－Ⅲ（ＡＴ－Ⅲ）和纤维结合蛋白（Ｆｎ）含量，应用ＥＬＩＳＡ法测定Ｄ－二聚体（Ｄ－Ｄｉｍｅｒ）含量。另检测两组ＡＤＰ诱导的血小板聚集率（ＰＡＧＴ）。结果：妊高征病人Ｆｎ，Ｄ－Ｄｉｍｅｒ和ＰＡＧＴ均高于正常对照组（Ｐ均＜０．０１），而妊高征病人ＡＴ－Ⅲ却显著低于正常对照组（Ｐ＜０．０１）。结论：妊高征病人存在凝血和纤溶功能变化，提示凝血和纤溶功能失调在妊高征发病中可能起重要作用
In order to understand the changes of coagulation and fibrinolytic function in patients with PIH, 24 patients with severe PIH were selected as the PIH group and 30 normal pregnant women as the control group. The plasma antithrombin-Ⅲ (AT-Ⅲ) and fibronectin (Fn) contents were detected by immunogold rocket electrophoresis. The content of D-dimer was determined by ELISA. The other two groups of ADP-induced platelet aggregation (PAGT) were also detected. Results: Fn, D-Dimer and PAGT in PIH patients were higher than those in normal controls (all P <0.01), while those in PIH patients were significantly lower than those in normal controls (P <0.01) . CONCLUSION: The changes of coagulation and fibrinolysis in patients with PIH suggest that dysfunction of coagulation and fibrinolysis may play an important role in the pathogenesis of PIH