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目的 研究低剂量、短期使用吉粒芬治疗化疗所致粒细胞减少的临床疗效。方法 10 8例患者随机分A、B、C3组。A组吉粒芬 75μg qd× 3d ;B组吉粒芬 75μg qod× 6d ;C组吉粒芬75μg qd× 5d。均为皮下注射。 结果 低剂量、短期使用吉粒芬在粒细胞降至 150 0× 10 9 L以上时有效 ,副作用少 ,能使患者安然度过粒细胞下降易感染期 ,以B组隔日使用疗效最好。结论 低剂量、短期使用吉粒芬可在粒细胞未降至 150 0× 10 9 L以上时使用有效 ,量不变隔日用效果更好。
Objective To study the clinical efficacy of low dosage and short-term use of jihuanfen in the treatment of chemotherapy-induced neutropenia. Methods One hundred and eight patients were randomly divided into A, B and C3 groups. A group Ji granule 75μg qd × 3d; B group Ji granule 75μg qod × 6d; C group Ji granule 75μg qd × 5d. Subcutaneous injection. Results Low-dose, short-term use of Kyrgyzstanfen in the granulocytes down to 150 0 × 10 9 L or more effective, less side effects, enabling patients to safely survive the granulocyte decline prone to infection, the best effect of the use of B group every other day. Conclusion Low-dose, short-term use of jihuanfenfen when the neutropenia did not drop to 150 0 × 10 9 L above the effective use of the same amount of every other effect is better.