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通过体内和体外试验，研究了草甘膦对大鼠肝微粒体酶、脂质过氧化作用及还原型谷胱甘肽的影响。体内试验结果表明：草甘膦能显著诱导增加微粒体细胞色素Ｐ（４５０）含量，与对照组比较［ｘ±ｓ（下同）分别为（０．６８±０．１２）、（０．５９±０．０９）μｍｏｌ／ｇ］具有显著意义（Ｐ＜０．０５）。并且可使还原型谷胱甘肽的含量显著增加，与对照组比较［分别为（１２８１．５±７４．０）、（１１７８．９±２２．０）μｇ／ｇ］具有极显著意义（Ｐ＜０．０１）。体外试验结果表明：草甘膦在１０（－８）～１０（－４）ｍｏｌ／Ｌ浓度范围内对细胞色素Ｐ（４５０）无明显影响，但能显著抑制脂质过氧化作用，在１０（－７）～１０（－４）ｍｏｌ／Ｌ时可增加还原型谷胱甘肽的含量，且呈明显剂量效应关系。
The effects of glyphosate on hepatic microsomal enzymes, lipid peroxidation and reduced glutathione in rats were studied in vivo and in vitro. The results of in vivo experiments showed that glyphosate significantly increased the content of microsomal cytochrome P (450), compared with the control group (x ± s (the same below) were (0.68 ± 0.12), ± 0.09) μmol / g] (P <0.05). (1281.5 ± 74.0) and (1178.9 ± 22.0) μg / g, respectively] were significantly increased compared with the control group (P <0.01). The results of in vitro experiments showed that glyphosate had no significant effect on cytochrome P (450) in the concentration range of 10 (-8) -10 (-4) mol / L, but could significantly inhibit lipid peroxidation, -7) ~ 10 (-4) mol / L can increase the content of reduced glutathione, and showed a significant dose-response relationship.