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目的:探讨剖宫产围手术期短疗程使用抗生素的疗效,为临床治疗提供客观依据。方法:采用随机对照设计,选择258例峨眉山市人民医院妇产科行剖宫产术的产妇,分为A、B、C 3组,每组各86例,A组在术中断脐后使用头孢拉定,B组在术后给予头孢拉定持续2天,C组在术后给予头孢拉定持续4天,观察3组使用抗生素的疗效差异。结果:术后最高体温、术后退烧时间、术后发病率、腹部切口感染以及子宫内膜炎3组组间比较,差异有统计学意义(P<0.05),B组与C组之间比较,差异无统计学意义(P>0.05);3组消化道反应、药物性皮疹、术后白细胞数和中性粒细胞数之间比较,差异无统计学意义(P>0.05)。结论:剖宫产围手术期短疗程使用抗生素可有效预防产后感染,减少术后不良反应的发生率。
Objective: To explore the curative effect of short courses of antibiotics in cesarean section perioperative period, and to provide objective evidence for clinical treatment. Methods: A randomized controlled design was used to select 258 mothers of the Cesarean section of People’s Hospital of Emeishan City, divided into groups A, B and C, 86 cases in each group. Group A received cephradine after the umbilicus was interrupted , B group given cefradine for 2 days after operation, C group given cephradine for 4 days after operation, and observed the difference of curative effect between 3 groups using antibiotics. Results: There were significant differences in postoperative maximum body temperature, postoperative fever, postoperative morbidity, abdominal incision infection and endometritis between the three groups (P <0.05), between the two groups (P> 0.05). There was no significant difference in digestive tract reaction, drug-induced rash, white blood cell count and neutrophil count between the three groups (P> 0.05). Conclusion: Cesarean section with a short course of perioperative antibiotics can effectively prevent postpartum infection and reduce the incidence of postoperative adverse reactions.