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目的探讨慢性乙型肝炎重叠戊型肝炎感染诊治特点。方法选择70例慢性乙型肝炎重叠戊型肝炎感染患者为观察组,70例慢性乙型肝炎感染患者为对照组,进行比较分析。结果两组总胆红素、丙氨酸氨基转移酶、凝血酶原活动度、天冬氨酸氨基转移酶、血白蛋白有统计学差异(P<0.01)。观察组HBeAg阴转率、HBV-DNA阳性率低于对照组(P<0.01)。结论慢性乙型肝炎重叠戊型肝炎感染会导致病情急剧加重,形成重症化,但是戊型肝炎病毒对乙肝病毒复制有一定程度的抑制作用。
Objective To investigate the diagnosis and treatment of overlapping hepatitis E in chronic hepatitis B. Methods Seventy patients with hepatitis E overlap hepatitis E infection were selected as the observation group and 70 patients with chronic hepatitis B infection as the control group for comparative analysis. Results There were significant differences in total bilirubin, alanine aminotransferase, prothrombin activity, aspartate aminotransferase and serum albumin (P <0.01). The negative rate of HBeAg and the positive rate of HBV-DNA in the observation group were lower than those in the control group (P <0.01). Conclusions Chronic Hepatitis B infection with overlapping Hepatitis E causes severe illness and aggravation of symptoms. However, Hepatitis E virus inhibits hepatitis B virus replication to a certain extent.