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钠泵与钠、钾-ATP酶钠泵(又称钠钾泵)是指细胞膜上具有主动转运钠钾离子功能的一种分子机构。在人和动物机体细胞膜内外,存在明显的电化学梯度,使钠钾离子分布具有很大的差异:细胞内呈高钾、低钠和负电势。这种差异须消耗机体的能量方得以维持。钠泵利用ATP水解释放的能量来对抗电化学梯度,实现钠钾离子的主动转运:泵出钠,泵入钾。1957年,Skou首先在一种蟹神经中发现了钠、钾依赖性三磷酸腺苷酶(钠、钾ATP酶,Na、K-ATPase,EC 3.6.1.3)。1965年,他证明了钠、钾-ATP酶具有与钠泵相同的性质:①位于
Sodium pump and sodium, potassium - ATP enzyme sodium pump (also known as sodium-potassium pump) is a cell membrane active transport of sodium and potassium function of a molecular mechanism. In human and animal body cell membrane, there is a clear electrochemical gradient, the distribution of sodium and potassium ions have great differences: intracellular high potassium, low sodium and negative potential. This difference must consume the energy of the body to maintain. Sodium pumps use the energy released by ATP hydrolysis to counteract electrochemical gradients, enabling the active transport of sodium and potassium ions: pump out sodium and pump it in. In 1957, Skou first discovered sodium and potassium-dependent adenosine triphosphatases (sodium and potassium ATPase, Na, K-ATPase, EC 3.6.1.3) in a crab nerve. In 1965 he demonstrated that sodium, potassium-ATPase has the same properties as sodium pumps: (1) located